Program

Time Table

Introduction to the Program

March 23, Saturday　15:20 – 16:10
Special Lecture　　English
Chair：Surjit Singh（Post Graduate Institute of Medical Education and Research：PGIMER, Chandigarh, India）
Speaker：Luigi D. Notarangelo (National Institute of Health, USA)

Dr Luigi Notarangelo has been making significant contributions to both clinical and basic immunology. His recent achievements include identification of IEI-causing genes, elucidation of immune abnormalities in MIS-C after COVID-19, and the development of thymic organoid systems that can intricately assess early T-cell differentiation in humans, to name a few. In this lecture, he will talk about multi-omics approach to unravel the diverse phenotypic manifestations of RAG deficiency, expanding our understanding of the disease spectrum.

March 23, Saturday　16:20 – 17:10
Plenary Lecture　　English
Inborn errors of immunity as a cause of inflammatory bowel disease.
Chair：Hirokazu Kanegane（Tokyo Medical and Dental University, Japan）
Speaker：Holm Uhlig（University of Oxford, UK）

Advancements in the identification of monogenic inflammatory bowel disease (IBD) are enhancing the understanding of molecular pathogenesis, leading to the development of molecular targeted therapies. A world-leading researcher in Very Early Onset IBD (VEO-IBD) will provide an overview of recent findings in IBD research.

March 23, Saturday　17:20 – 18:10
Chairperson’s Lecture　　English
D’où venons-nous? Que sommes-nous? Où allons-nous?
Chair：Tomohiro Morio（Tokyo Medical and Dental University, Japan）
Speaker：Hirokazu Kanegane（Tokyo Medical and Dental University, Japan）

D’où venons-nous? Que sommes-nous? Où allons-nous? “Where do we come from? What are we? Where are we going?” By focusing on the problem we find in the field of inborn errors of immunity, Dr Kanegane answer the fundamental question of where we come from. How much will we enjoy this lecture?

March 24, Sunday　8:00 – 9:20
APSID Symposium１　　English
Hematopoietic cell transplantation for inborn errors of immunity
Chairs：Luigi D. Notarangelo　(National Institute of Health, USA), Masataka Ishimura（Kyushu University, Japan）
Speakers：Fulvio Porta（Children’s Hospital Brescia, Italy）, Pamela Pui Wah Lee（University of Hong Kong）, Satoshi Miyamoto（Tokyo Medical and Dental University, Japan）

The curative treatment for many inborn errors of immunity (IEI) is hematopoietic cell transplantation (HCT). Due to differences in disease prevalence, healthcare resources, and systems, the practices of HCT for IEI vary significantly among countries. This symposium will focus on discussing the expanded use of HCT for IEI in countries participating in APSID.

March 24, Sunday　10:50 – 12:10
APSID Symposium２　　English
Basic research for inborn errors of immunity
Chairs：Yoshiyuki Minegishi（Tokushima University, Japan）, Hans D. Ochs（Washington University, USA）
Speakers：David Lewis（Stanford University, USA）, Wenwei Tu（University of Hong Kong）, Kazuyuki Meguro（Chiba University, Japan）

In the elucidation of the pathogenesis of inborn errors of immunity (IEI), the role played by basic research is substantial, contributing to advancements from understanding the pathology to the development of novel therapeutic interventions. Leading researchers in these fields will provide insights into recent studies contributing to the understanding of the pathogenesis and novel therapeutic approaches of IEI.

March 22, Friday　10:20 – 11:50
JSIAD Symposium１　　Japanese
Newborn Screening for Primary Immunodeficiencies
Chairs：Tomoyuki Mizukami（National Hospital Organization Kumamoto Medical Center, Japan）, Hideki Muramatsu（Nagoya University Hospital, Japan）
Speakers：Nobuyuki Ishige（Tokyo Health Service Association）, Manabu Wakamatsu（Nagoya University, Japan）, Dan Tomomasa（Tokyo Medical and Dental University, Japan）, Yin-Hsiu Chien（National Taiwan University Hospital, Taiwan）, Takahiro Yasumi（Kyoto University, Japan）

Broad utilization of newborn screening for primary immunodeficiency disorders (PID) and early diagnosis is one of the most crucial challenges for timely therapeutic intervention and a significantly improved prognosis for affected individuals. Newborn screening for PID has expanded in Japan since the 2010s, and this symposium will explore the accumulating knowledge in this field.

March 22, Friday　13:40 – 15:10
JSIAD Symposium２　　Japanese
The Latest Trends in Adult Inflammatory Diseases
Chairs：Kiyoshi Migita（Fukushima Medical University, Japan）, Hiroaki Ida（Kurume University, Japan）
Speakers：Yohei Kirino（Yokohama City University, Japan）、Tomohiro Koga（Nagasaki University Hospital, Japan）、Osamu Kohara（Kazusa DNA Research Institute, Japan）、Kazushi Izawa（Kyoto University, Japan）

In recent years, there has been increasing attention to the diverse pathophysiology and clinical manifestations of autoinflammatory disorders in adulthood. This symposium will address the challenges of comprehending the overall picture of adult autoinflammatory disorders from various perspectives.

JSIAD Educational Lecture　　Japanese
Chairs：Hidetoshi Takada（Tsukuba University）
１．Interpretation of Flow Cytometry Test Results
Speaker：Akihiro Hoshino（Tokyo Medical and Dental University, Japan）
２．The outline of the Primary Immunodeficiency Database in Japan 2 and the process of requesting genetic testing.
Speaker：Satoshi Okada（Hiroshima University）

This educational session covers the interpretation of lymphocyte subset analysis using flow cytometry, which is essential for diagnosing various inborn errors of immunity. Additionally, an overview will be provided on the patient registry PIDJ2 and genetic testing in Japan.

IEI School 2024 March 22, 2024, Friday　English Session

This school aims to train a younger generation of IEI experts, where participants can share their clinical experiences and stay updated on the latest research information. We eagerly anticipate the participation of young researchers.

Each session will consist of a lecture by the invited speaker, three general presentations on the session theme, and a question-and-answer session. A post-evaluation quiz will be held at the end of the school.